Newly minted artist Rose Maning is thrilled with the positive reception of her first gallery opening. Her success is empowering, yet the constant demands of work make planning her wedding to Lyon impossible. To complicate matters further, her conservator friend Beatrice uncovers a mysterious clue to a centuries-old mystery that involves a lost Leonardo da Vinci painting.

Rose heads to the Eternal City of Rome to uncover a fierce rivalry between two of the greatest Renaissance masters: Michelangelo and Leonardo da Vinci. The past and the present intertwine when Beatrice becomes enthralled by a street artist named Mike. He and his nemesis, Vince, create thought-provoking murals that challenge people to look at history through a different lens.

As they search for the lost Leonardo, Rose learns some hard lessons about greed and the healing power of love.